Thrombin-activable fibrinolysis inhibitor (TAFI) zymogen is an active carboxypeptidase.


Journal Article

Thrombin-activable fibrinolysis inhibitor (TAFI) is a carboxypeptidase found in human plasma, presumably as an inactive zymogen. The current dogma is that proteolytic activation by thrombin/thrombomodulin generates the active enzyme (TAFIa), which down-regulates fibrinolysis by removing C-terminal lysine residues from partially degraded fibrin. In this study, we have shown that the zymogen exhibits continuous and stable carboxypeptidase activity against large peptide substrates, and we suggest that the activity down-regulates fibrinolysis in vivo.

Full Text

Cited Authors

  • Valnickova, Z; Thøgersen, IB; Potempa, J; Enghild, JJ

Published Date

  • February 2007

Published In

Volume / Issue

  • 282 / 5

Start / End Page

  • 3066 - 3076

PubMed ID

  • 17138567

Pubmed Central ID

  • 17138567

Electronic International Standard Serial Number (EISSN)

  • 1083-351X

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.m606559200


  • eng