Long-term safety and efficacy of glipizide.


Journal Article

We studied the effect of long-term glipizide therapy in a small group of closely monitored patients. Fasting plasma glucose, glucose tolerance, glucose-stimulated insulin secretion, and insulin sensitivity were measured on multiple occasions throughout the investigation. Our observations show that glipizide therapy is effective in certain patients with noninsulin-dependent diabetes mellitus over a prolonged time period. The major effect of the drug appears to be mediated by its alteration of insulin sensitivity, but glipizide also causes a sustained increase in glucose-stimulated insulin secretion in most patients.

Full Text

Duke Authors

Cited Authors

  • Feinglos, MN; Lebovitz, HE

Published Date

  • November 30, 1983

Published In

Volume / Issue

  • 75 / 5B

Start / End Page

  • 60 - 66

PubMed ID

  • 6369969

Pubmed Central ID

  • 6369969

International Standard Serial Number (ISSN)

  • 0002-9343

Digital Object Identifier (DOI)

  • 10.1016/0002-9343(83)90255-3


  • eng

Conference Location

  • United States