Chronic primary intestinal pseudo-obstruction.

Journal Article (Journal Article)

Chronic primary intestinal pseudo-obstruction (CPIP) has received attention despite of its unclear etiology and infrequent occurrence. Recently a patient with this disorder had evidence of a primary visceral neuropathy. Reviewing the literature, we found 30 case reports of CPIP and evaluated their clinicopathologic findings. Presenting symptoms and radiologic findings were nonspecific. Esophageal motility was abnormal in 12 of 14 reports. Intestinal histopathology revealed normal muscle wall, mucosa, and ganglion cells in over 50% of reports. Only 48% of cases demonstrated clinical improvement. Thirty percent (8 of 30) ultimately died. We conclude that CPIP is a perplexing, often fatal entity that can mimic mechanical obstruction in the absence of definite etiology. Primary neurologic or muscular disease may be a possible explanation, but, as yet, definite documentation does not exist.

Full Text

Duke Authors

Cited Authors

  • Hanks, JB; Meyers, WC; Andersen, DK; Woodard, BH; Peete, WP; Garbutt, JT; Jones, RS

Published Date

  • February 1, 1981

Published In

Volume / Issue

  • 89 / 2

Start / End Page

  • 175 - 182

PubMed ID

  • 6893876

International Standard Serial Number (ISSN)

  • 0039-6060


  • eng

Conference Location

  • United States