Shedding UV light on alternative splicing.


Journal Article

After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.

Full Text

Duke Authors

Cited Authors

  • Marengo, MS; Garcia-Blanco, MA

Published Date

  • May 15, 2009

Published In

Volume / Issue

  • 137 / 4

Start / End Page

  • 600 - 602

PubMed ID

  • 19450507

Pubmed Central ID

  • 19450507

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2009.04.054


  • eng

Conference Location

  • United States