Co-regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac.

Journal Article (Journal Article)

Nitric oxide (NO), generated by NO synthases (NOSs), has multifarious roles in signal transduction. Reactive oxygen species (ROS), generated by ubiquitous NADPH oxidases (NOXs), also participate in cellular signaling. However, the coordination of signals conveyed by NO and ROS is poorly understood. We show that the small GTPase Rac, a component of some NOXs, also interacts with and regulates the constitutively-expressed NOSs. Cellular NO and O(2)(-) production increase or decrease together following activation or inhibition of Rac, and Rac inhibition reveals transduction mechanisms that depend upon NO (vasodilation), ROS (actin polymerization) or both (cytoskeletal organization). Thus, signaling by NO and ROS may be coordinated through a common control element.

Full Text

Duke Authors

Cited Authors

  • Selvakumar, B; Hess, DT; Goldschmidt-Clermont, PJ; Stamler, JS

Published Date

  • June 25, 2008

Published In

Volume / Issue

  • 582 / 15

Start / End Page

  • 2195 - 2202

PubMed ID

  • 18501711

Pubmed Central ID

  • 18501711

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2008.04.062


  • eng

Conference Location

  • England