Gene by sex interaction for measures of obesity in the framingham heart study.

Journal Article (Journal Article)

Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-sex interaction in any individual exam, four polymorphisms displayed a consistent BMI association (P-values .00186 to .00010) across all five exams. These variants were clustered downstream of LYPLAL1, which encodes a lipase/esterase expressed in adipose tissue, a locus previously identified as having sex-specific effects on central obesity. Primary effects in males were in the opposite direction from females and were replicated in Framingham Generation 3. Our data support a sex-influenced association between genetic variation at the LYPLAL1 locus and obesity-related traits.

Full Text

Duke Authors

Cited Authors

  • Benjamin, AM; Suchindran, S; Pearce, K; Rowell, J; Lien, LF; Guyton, JR; McCarthy, JJ

Published Date

  • 2011

Published In

Volume / Issue

  • 2011 /

Start / End Page

  • 329038 -

PubMed ID

  • 21253498

Pubmed Central ID

  • PMC3021872

Electronic International Standard Serial Number (EISSN)

  • 2090-0716

Digital Object Identifier (DOI)

  • 10.1155/2011/329038


  • eng

Conference Location

  • United States