Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing.

Journal Article (Journal Article)

Allopurinol is the most commonly used drug for the treatment of hyperuricemia and gout. However, allopurinol is also one of the most common causes of severe cutaneous adverse reactions (SCARs), which include drug hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis. A variant allele of the human leukocyte antigen (HLA)-B, HLA-B*58:01, associates strongly with allopurinolinduced SCAR. We have summarized the evidence from the published literature and developed peer-reviewed guidelines for allopurinol use based on HLA-B genotype.

Full Text

Duke Authors

Cited Authors

  • Hershfield, MS; Callaghan, JT; Tassaneeyakul, W; Mushiroda, T; Thorn, CF; Klein, TE; Lee, MTM

Published Date

  • February 2013

Published In

Volume / Issue

  • 93 / 2

Start / End Page

  • 153 - 158

PubMed ID

  • 23232549

Pubmed Central ID

  • PMC3564416

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

Digital Object Identifier (DOI)

  • 10.1038/clpt.2012.209


  • eng

Conference Location

  • United States