Methionine-enkephalin and morphine: amount ejected microiontophoretically.


Journal Article

The microiontophoretic transport numbers of Met-enkephalin and morphine were determined by ejecting the tritiated compounds from both 5-barrel and 7-barrel micro-pipettes into a small volume of 0.9% NaCl, using a series of ejection currents and various timed durations. The transport number of Met-enkephalin was 2-4 times less than that for morphine in 5- and 7-barrel pipettes. The transport numbers of both drugs in 5-barrel pipettes were significantly greater than those in 7-barrel pipettes. These results indicate the need for caution in comparing the data derived from different studies that use microiontophoresis. The transport numbers for morphine and Met-enkephalin were used to compare the effects of these agents on neuronal firing.

Full Text

Cited Authors

  • Hosford, DA; Haigler, HJ; Turner, RS

Published Date

  • August 1981

Published In

Volume / Issue

  • 4 / 2

Start / End Page

  • 135 - 139

PubMed ID

  • 7278364

Pubmed Central ID

  • 7278364

Electronic International Standard Serial Number (EISSN)

  • 1872-678X

International Standard Serial Number (ISSN)

  • 0165-0270

Digital Object Identifier (DOI)

  • 10.1016/0165-0270(81)90047-9


  • eng