Skip to main content
Journal cover image

hCG, progesterone, alpha-fetoprotein, and estradiol in the identification of ectopic pregnancy.

Publication ,  Journal Article
Grosskinsky, CM; Hage, ML; Tyrey, L; Christakos, AC; Hughes, CL
Published in: Obstet Gynecol
May 1993

OBJECTIVE: To enhance the laboratory diagnosis of ectopic pregnancy by determining levels of hCG, progesterone, estradiol (E2), and alpha-fetoprotein (AFP). METHODS: Serum samples and medical records were retrospectively analyzed from 100 gynecologic patients for whom quantitative hCG determination had been ordered. Clinical data and levels of hCG, progesterone, E2, and AFP were examined by univariate and multivariate logistic analyses. RESULTS: Progesterone, hCG, and E2 were highest in viable pregnancies, whereas AFP tended to be higher in ectopic pregnancies. A single progesterone value could differentiate between ectopic and viable pregnancy in more than 80% of patients. The combination of all four biochemical markers predicted ectopic pregnancy with 98.5% specificity and 94.5% accuracy. Clinical diagnosis was less than 75% accurate. CONCLUSION: A combination of biochemical markers including hCG, progesterone, E2, and AFP can be superior to a single progesterone level or clinical evaluation in the diagnosis of ectopic pregnancy.

Duke Scholars

Published In

Obstet Gynecol

ISSN

0029-7844

Publication Date

May 1993

Volume

81

Issue

5 ( Pt 1)

Start / End Page

705 / 709

Location

United States

Related Subject Headings

  • alpha-Fetoproteins
  • Retrospective Studies
  • Progesterone
  • Pregnancy, Ectopic
  • Pregnancy
  • Predictive Value of Tests
  • Obstetrics & Reproductive Medicine
  • Multivariate Analysis
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Grosskinsky, C. M., Hage, M. L., Tyrey, L., Christakos, A. C., & Hughes, C. L. (1993). hCG, progesterone, alpha-fetoprotein, and estradiol in the identification of ectopic pregnancy. Obstet Gynecol, 81(5 ( Pt 1)), 705–709.
Grosskinsky, C. M., M. L. Hage, L. Tyrey, A. C. Christakos, and C. L. Hughes. “hCG, progesterone, alpha-fetoprotein, and estradiol in the identification of ectopic pregnancy.Obstet Gynecol 81, no. 5 ( Pt 1) (May 1993): 705–9.
Grosskinsky CM, Hage ML, Tyrey L, Christakos AC, Hughes CL. hCG, progesterone, alpha-fetoprotein, and estradiol in the identification of ectopic pregnancy. Obstet Gynecol. 1993 May;81(5 ( Pt 1)):705–9.
Grosskinsky, C. M., et al. “hCG, progesterone, alpha-fetoprotein, and estradiol in the identification of ectopic pregnancy.Obstet Gynecol, vol. 81, no. 5 ( Pt 1), May 1993, pp. 705–09.
Grosskinsky CM, Hage ML, Tyrey L, Christakos AC, Hughes CL. hCG, progesterone, alpha-fetoprotein, and estradiol in the identification of ectopic pregnancy. Obstet Gynecol. 1993 May;81(5 ( Pt 1)):705–709.
Journal cover image

Published In

Obstet Gynecol

ISSN

0029-7844

Publication Date

May 1993

Volume

81

Issue

5 ( Pt 1)

Start / End Page

705 / 709

Location

United States

Related Subject Headings

  • alpha-Fetoproteins
  • Retrospective Studies
  • Progesterone
  • Pregnancy, Ectopic
  • Pregnancy
  • Predictive Value of Tests
  • Obstetrics & Reproductive Medicine
  • Multivariate Analysis
  • Humans
  • Female