Tetracycline-induced bile duct paucity and prolonged cholestasis.
Publication
, Journal Article
Hunt, CM; Washington, K
Published in: Gastroenterology
December 1994
Acute self-limited liver disease has been associated with tetracycline use. However, severe prolonged cholestatic hepatitis and bile duct paucity have not been previously attributed to tetracyclines. Hepatitis, characterized by prolonged jaundice, severe pruritus, and moderate increased transaminase values, occurred within 2 months of ingesting tetracyclines in two female patients. Serum bilirubin levels normalized 12 and 34 months after tetracycline ingestion. Liver histology revealed bile duct paucity, severe cholestasis, and minimal necrosis and inflammation. Tetracyclines may infrequently induce bile duct paucity and prolonged, severe, and reversible cholestasis.
Duke Scholars
Published In
Gastroenterology
DOI
ISSN
0016-5085
Publication Date
December 1994
Volume
107
Issue
6
Start / End Page
1844 / 1847
Location
United States
Related Subject Headings
- Tetracycline
- Necrosis
- Middle Aged
- Liver
- Humans
- Gastroenterology & Hepatology
- Female
- Cholestasis
- Chemical and Drug Induced Liver Injury
- Bile Ducts
Citation
APA
Chicago
ICMJE
MLA
NLM
Hunt, C. M., & Washington, K. (1994). Tetracycline-induced bile duct paucity and prolonged cholestasis. Gastroenterology, 107(6), 1844–1847. https://doi.org/10.1016/0016-5085(94)90830-3
Hunt, C. M., and K. Washington. “Tetracycline-induced bile duct paucity and prolonged cholestasis.” Gastroenterology 107, no. 6 (December 1994): 1844–47. https://doi.org/10.1016/0016-5085(94)90830-3.
Hunt CM, Washington K. Tetracycline-induced bile duct paucity and prolonged cholestasis. Gastroenterology. 1994 Dec;107(6):1844–7.
Hunt, C. M., and K. Washington. “Tetracycline-induced bile duct paucity and prolonged cholestasis.” Gastroenterology, vol. 107, no. 6, Dec. 1994, pp. 1844–47. Pubmed, doi:10.1016/0016-5085(94)90830-3.
Hunt CM, Washington K. Tetracycline-induced bile duct paucity and prolonged cholestasis. Gastroenterology. 1994 Dec;107(6):1844–1847.
Published In
Gastroenterology
DOI
ISSN
0016-5085
Publication Date
December 1994
Volume
107
Issue
6
Start / End Page
1844 / 1847
Location
United States
Related Subject Headings
- Tetracycline
- Necrosis
- Middle Aged
- Liver
- Humans
- Gastroenterology & Hepatology
- Female
- Cholestasis
- Chemical and Drug Induced Liver Injury
- Bile Ducts