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Analysis of current multiple sclerosis registries.

Publication ,  Journal Article
Hurwitz, BJ
Published in: Neurology
January 4, 2011

BACKGROUND: Patient registries are valuable because they provide data that cannot be captured in any other way. Observations from registry studies are particularly informative if multiple registries confirm similar findings. A selection of multiple sclerosis (MS) registry studies were reviewed, and results and consistency of those studies are presented. METHODS: A panel of experts analyzed the study findings of established MS registries and presented their conclusions on the overall results and consistency of those studies. RESULTS: A review of evidence from MS registry studies reveals similar findings with respect to patterns of disability progression, predictors of disability progression, and changes in lifespan. Several registries show that progression after Expanded Disability Status Scale (EDSS) 4 occurs at a predictable rate, and once EDSS 4 is reached, subsequent progression rates are similar regardless of the type of MS at onset. Clinicians, payers, and patients need to understand that MS may shorten life expectancy. The mortality data derived from registries reveal higher death rates in patients with MS compared with the general population, indicating that MS is an important public health issue. CONCLUSIONS: The key findings in registries should be utilized in conjunction with data from clinical trials to optimize treatment and improve long-term outcomes.

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Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

January 4, 2011

Volume

76

Issue

1 Suppl 1

Start / End Page

S7 / 13

Location

United States

Related Subject Headings

  • United States
  • Registries
  • Quality of Life
  • Neurology & Neurosurgery
  • Multiple Sclerosis
  • Humans
  • Europe
  • Disease Progression
  • Disability Evaluation
  • Databases, Factual
 

Citation

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Hurwitz, B. J. (2011). Analysis of current multiple sclerosis registries. Neurology, 76(1 Suppl 1), S7-13. https://doi.org/10.1212/WNL.0b013e31820502f6
Hurwitz, Barrie J. “Analysis of current multiple sclerosis registries.Neurology 76, no. 1 Suppl 1 (January 4, 2011): S7-13. https://doi.org/10.1212/WNL.0b013e31820502f6.
Hurwitz BJ. Analysis of current multiple sclerosis registries. Neurology. 2011 Jan 4;76(1 Suppl 1):S7-13.
Hurwitz, Barrie J. “Analysis of current multiple sclerosis registries.Neurology, vol. 76, no. 1 Suppl 1, Jan. 2011, pp. S7-13. Pubmed, doi:10.1212/WNL.0b013e31820502f6.
Hurwitz BJ. Analysis of current multiple sclerosis registries. Neurology. 2011 Jan 4;76(1 Suppl 1):S7-13.

Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

January 4, 2011

Volume

76

Issue

1 Suppl 1

Start / End Page

S7 / 13

Location

United States

Related Subject Headings

  • United States
  • Registries
  • Quality of Life
  • Neurology & Neurosurgery
  • Multiple Sclerosis
  • Humans
  • Europe
  • Disease Progression
  • Disability Evaluation
  • Databases, Factual