An ontology-based segmentation scheme for tracking postnatal changes in the developing rodent brain with MRI.

Published

Journal Article

The postnatal period of neurodevelopment has been implicated in a number of brain disorders including autism and schizophrenia. Rodent models have proven to be invaluable in advancing our understanding of the human brain, and will almost certainly play a pivotal role in future studies on postnatal neurodevelopment. The growing field of magnetic resonance microscopy has the potential to revolutionize our understanding of neurodevelopment, if it can be successfully and appropriately assimilated into the vast body of existing neuroscience research. In this study, we demonstrate the utility of a developmental neuro-ontology designed specifically for tracking regional changes in MR biomarkers throughout postnatal neurodevelopment. Using this ontological classification as a segmentation guide, we track regional changes in brain volume in rats between postnatal day zero and postnatal day 80 and demonstrate differential growth rates in axial versus paraxial brain regions. Both the ontology and the associated label volumes are provided as a foundation for future MR-based studies of postnatal neurodevelopment in normal and disease states.

Full Text

Duke Authors

Cited Authors

  • Calabrese, E; Johnson, GA; Watson, C

Published Date

  • February 15, 2013

Published In

Volume / Issue

  • 67 /

Start / End Page

  • 375 - 384

PubMed ID

  • 23246176

Pubmed Central ID

  • 23246176

Electronic International Standard Serial Number (EISSN)

  • 1095-9572

Digital Object Identifier (DOI)

  • 10.1016/j.neuroimage.2012.11.037

Language

  • eng

Conference Location

  • United States