Stent thrombosis associated with first-generation drug-eluting stents: issues with antiplatelet therapy.


Journal Article

Notice of the rare but catastrophic occurrence of stent thrombosis in association with deployment of drug-eluting stents has focused attention on the adequacy of the current dual antiplatelet regimen of aspirin and clopidogrel. Some patients will not respond to clopidogrel and a glycoprotein (GP) IIb/IIIa inhibitor may be strongly considered during stenting procedures, especially in high-risk patients or those not receiving pretreatment with clopidogrel. Insisting upon and confirming adherence to antiplatelet therapy are complicated tasks, especially because the reasons for premature discontinuation are myriad, from cost to bleeding complications to the need for minor surgery. Nevertheless, the concern about adherence to antiplatelet therapy represents a new and significant clinical reality in our stenting era, one previously less appreciated with the deployment of bare metal stents. (Neth Heart J 2007;15:148-50.).

Full Text

Duke Authors

Cited Authors

  • Gurbel, PA; Kandzari, DE

Published Date

  • 2007

Published In

Volume / Issue

  • 15 / 4

Start / End Page

  • 148 - 150

PubMed ID

  • 17612675

Pubmed Central ID

  • 17612675

International Standard Serial Number (ISSN)

  • 1568-5888

Digital Object Identifier (DOI)

  • 10.1007/bf03085971


  • eng

Conference Location

  • Netherlands