Context-dependent regulation of Wnt signaling through the primary cilium.

Journal Article (Review)

The primary cilium is a highly conserved environmental sensor and modulator of fluid movement in tubular structures. The growing recognition of mutations among its many components has led to the discovery of new disorders collectively called ciliopathies. Ciliary dysfunction disturbs a variety of signaling pathways along its basal body and axoneme that are critical for embryonic development and cell and organ homeostasis. Among the many pathways, here we discuss the emerging role of Wnt proteins in morphogenic signaling and ciliary biology during health and disease.

Full Text

Duke Authors

Cited Authors

  • Oh, EC; Katsanis, N

Published Date

  • January 2013

Published In

Volume / Issue

  • 24 / 1

Start / End Page

  • 10 - 18

PubMed ID

  • 23123400

Electronic International Standard Serial Number (EISSN)

  • 1533-3450

Digital Object Identifier (DOI)

  • 10.1681/ASN.2012050526

Language

  • eng

Conference Location

  • United States