G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.
Journal Article (Journal Article;Review)
G-protein-coupled receptor signaling and receptor tyrosine kinase (RTK) signaling are two mechanisms of transmembrane communication used by numerous extracellular agents and stimuli. The beta gamma-subunit complex of G proteins mediates many of the functions associated with G-protein-coupled receptor signaling and may even provide a means to link G proteins to RTK-initiated cascades. This connection may be mediated by the pleckstrin homology domain, a modular domain found in many signaling proteins that interact with G beta gamma.
Full Text
Duke Authors
Cited Authors
- Inglese, J; Koch, WJ; Touhara, K; Lefkowitz, RJ
Published Date
- April 1995
Published In
Volume / Issue
- 20 / 4
Start / End Page
- 151 - 156
PubMed ID
- 7770915
International Standard Serial Number (ISSN)
- 0968-0004
Digital Object Identifier (DOI)
- 10.1016/s0968-0004(00)88992-6
Language
- eng
Conference Location
- England