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G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.

Publication ,  Journal Article
Inglese, J; Koch, WJ; Touhara, K; Lefkowitz, RJ
Published in: Trends Biochem Sci
April 1995

G-protein-coupled receptor signaling and receptor tyrosine kinase (RTK) signaling are two mechanisms of transmembrane communication used by numerous extracellular agents and stimuli. The beta gamma-subunit complex of G proteins mediates many of the functions associated with G-protein-coupled receptor signaling and may even provide a means to link G proteins to RTK-initiated cascades. This connection may be mediated by the pleckstrin homology domain, a modular domain found in many signaling proteins that interact with G beta gamma.

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Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

April 1995

Volume

20

Issue

4

Start / End Page

151 / 156

Location

England

Related Subject Headings

  • ras Proteins
  • Signal Transduction
  • Receptor Protein-Tyrosine Kinases
  • Phosphoproteins
  • Humans
  • GTP-Binding Proteins
  • Developmental Biology
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Blood Proteins
  • Binding Sites
 

Citation

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Inglese, J., Koch, W. J., Touhara, K., & Lefkowitz, R. J. (1995). G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. Trends Biochem Sci, 20(4), 151–156. https://doi.org/10.1016/s0968-0004(00)88992-6
Inglese, J., W. J. Koch, K. Touhara, and R. J. Lefkowitz. “G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.Trends Biochem Sci 20, no. 4 (April 1995): 151–56. https://doi.org/10.1016/s0968-0004(00)88992-6.
Inglese J, Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. Trends Biochem Sci. 1995 Apr;20(4):151–6.
Inglese, J., et al. “G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.Trends Biochem Sci, vol. 20, no. 4, Apr. 1995, pp. 151–56. Pubmed, doi:10.1016/s0968-0004(00)88992-6.
Inglese J, Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. Trends Biochem Sci. 1995 Apr;20(4):151–156.
Journal cover image

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

April 1995

Volume

20

Issue

4

Start / End Page

151 / 156

Location

England

Related Subject Headings

  • ras Proteins
  • Signal Transduction
  • Receptor Protein-Tyrosine Kinases
  • Phosphoproteins
  • Humans
  • GTP-Binding Proteins
  • Developmental Biology
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Blood Proteins
  • Binding Sites