G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.

Journal Article (Journal Article;Review)

G-protein-coupled receptor signaling and receptor tyrosine kinase (RTK) signaling are two mechanisms of transmembrane communication used by numerous extracellular agents and stimuli. The beta gamma-subunit complex of G proteins mediates many of the functions associated with G-protein-coupled receptor signaling and may even provide a means to link G proteins to RTK-initiated cascades. This connection may be mediated by the pleckstrin homology domain, a modular domain found in many signaling proteins that interact with G beta gamma.

Full Text

Duke Authors

Cited Authors

  • Inglese, J; Koch, WJ; Touhara, K; Lefkowitz, RJ

Published Date

  • April 1995

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 151 - 156

PubMed ID

  • 7770915

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/s0968-0004(00)88992-6


  • eng

Conference Location

  • England