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Quantitative surface-enhanced resonant Raman scattering multiplexing of biocompatible gold nanostars for in vitro and ex vivo detection.

Publication ,  Journal Article
Yuan, H; Liu, Y; Fales, AM; Li, YL; Liu, J; Vo-Dinh, T
Published in: Analytical chemistry
January 2013

Surface-enhanced Raman scattering (SERS)-active plasmonic nanomaterials have become a promising agent for molecular imaging and multiplex detection. To produce strong SERS intensity while retaining the nonaggregated state and biocompatibility needed for bioapplications, we integrated near-infrared (NIR) responsive plasmonic gold nanostars with resonant dyes for resonant SERS (SERRS). The SERRS on nanostars was several orders of magnitude greater than signals from SERRS on nanospheres and nonresonant SERS on nanostars. For the first time, we demonstrated quantitative multiplex detection using four unique nanostar SERRS probes in both in vitro solutions and ex vivo tissue samples under NIR excitation. With further optimization, in vivo tracking of multiple SERRS probes is possible.

Duke Scholars

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Published In

Analytical chemistry

DOI

EISSN

1520-6882

ISSN

0003-2700

Publication Date

January 2013

Volume

85

Issue

1

Start / End Page

208 / 212

Related Subject Headings

  • Spectrum Analysis, Raman
  • Skin
  • Serum Albumin, Bovine
  • Nanostructures
  • Gold
  • Fluorescent Dyes
  • Chickens
  • Cattle
  • Biocompatible Materials
  • Animals
 

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Yuan, H., Liu, Y., Fales, A. M., Li, Y. L., Liu, J., & Vo-Dinh, T. (2013). Quantitative surface-enhanced resonant Raman scattering multiplexing of biocompatible gold nanostars for in vitro and ex vivo detection. Analytical Chemistry, 85(1), 208–212. https://doi.org/10.1021/ac302510g
Yuan, Hsiangkuo, Yang Liu, Andrew M. Fales, You Leo Li, Jesse Liu, and Tuan Vo-Dinh. “Quantitative surface-enhanced resonant Raman scattering multiplexing of biocompatible gold nanostars for in vitro and ex vivo detection.Analytical Chemistry 85, no. 1 (January 2013): 208–12. https://doi.org/10.1021/ac302510g.
Yuan H, Liu Y, Fales AM, Li YL, Liu J, Vo-Dinh T. Quantitative surface-enhanced resonant Raman scattering multiplexing of biocompatible gold nanostars for in vitro and ex vivo detection. Analytical chemistry. 2013 Jan;85(1):208–12.
Yuan, Hsiangkuo, et al. “Quantitative surface-enhanced resonant Raman scattering multiplexing of biocompatible gold nanostars for in vitro and ex vivo detection.Analytical Chemistry, vol. 85, no. 1, Jan. 2013, pp. 208–12. Epmc, doi:10.1021/ac302510g.
Yuan H, Liu Y, Fales AM, Li YL, Liu J, Vo-Dinh T. Quantitative surface-enhanced resonant Raman scattering multiplexing of biocompatible gold nanostars for in vitro and ex vivo detection. Analytical chemistry. 2013 Jan;85(1):208–212.
Journal cover image

Published In

Analytical chemistry

DOI

EISSN

1520-6882

ISSN

0003-2700

Publication Date

January 2013

Volume

85

Issue

1

Start / End Page

208 / 212

Related Subject Headings

  • Spectrum Analysis, Raman
  • Skin
  • Serum Albumin, Bovine
  • Nanostructures
  • Gold
  • Fluorescent Dyes
  • Chickens
  • Cattle
  • Biocompatible Materials
  • Animals