Metabolic regulation of T lymphocytes.


Journal Article (Review)

T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP-generating processes, whereas proliferating effector T cells require high metabolic flux through growth-promoting pathways. Further, functionally distinct T cell subsets require distinct energetic and biosynthetic pathways to support their specific functional needs. Pathways that control immune cell function and metabolism are intimately linked, and changes in cell metabolism at both the cell and system levels have been shown to enhance or suppress specific T cell functions. As a result of these findings, cell metabolism is now appreciated as a key regulator of T cell function specification and fate. This review discusses the role of cellular metabolism in T cell development, activation, differentiation, and function to highlight the clinical relevance and opportunities for therapeutic interventions that may be used to disrupt immune pathogenesis.

Full Text

Duke Authors

Cited Authors

  • MacIver, NJ; Michalek, RD; Rathmell, JC

Published Date

  • 2013

Published In

Volume / Issue

  • 31 /

Start / End Page

  • 259 - 283

PubMed ID

  • 23298210

Pubmed Central ID

  • 23298210

Electronic International Standard Serial Number (EISSN)

  • 1545-3278

Digital Object Identifier (DOI)

  • 10.1146/annurev-immunol-032712-095956


  • eng

Conference Location

  • United States