Polysialic acid expression is not necessary for motor neuron target selectivity.

Journal Article (Journal Article)

INTRODUCTION: Recovery after peripheral nerve lesions depends on guiding axons back to their targets. Polysialic acid upregulation by regrowing axons has been proposed recently as necessary for this target selectivity. METHODS: We reexamined this proposition using a cross-reinnervation model whereby axons from obturator motor neurons that do not upregulate polysialic acid regenerated into the distal femoral nerve. Our aim was to assess their target selectivity between pathways to muscle and skin. RESULTS: After simple cross-repair, obturator motor neurons showed no pathway preference, but the same repair with a shortened skin pathway resulted in selective targeting of these motor neurons to muscle by a polysialic acid-independent mechanism. CONCLUSION: The intrinsic molecular differences between motor neuron pools can be overcome by manipulation of their access to different peripheral nerve pathways such that obturator motor neurons preferentially project to a terminal nerve branch to muscle despite not upregulating the expression of polysialic acid.

Full Text

Duke Authors

Cited Authors

  • Robinson, GA; Madison, RD

Published Date

  • March 2013

Published In

Volume / Issue

  • 47 / 3

Start / End Page

  • 364 - 371

PubMed ID

  • 23169481

Pubmed Central ID

  • PMC3740786

Electronic International Standard Serial Number (EISSN)

  • 1097-4598

Digital Object Identifier (DOI)

  • 10.1002/mus.23526


  • eng

Conference Location

  • United States