Onset of dyskinesia and changes in postural task performance during the course of neuroleptic withdrawal.

Journal Article (Journal Article)

The effect of neuroleptic withdrawal on postural task performance of 20 adults with mental retardation was examined. Dyskinesia was measured using the DISCUS rating scale and postural stability using a force platform during a prospective longitudinal neuroleptic medication withdrawal protocol. Assessments were conducted at baseline and monthly intervals, extending to approximately one year following complete medication withdrawal, when significant changes in amount of postural motion and sequential pattern of postural movement complexity were observed. Postural task performance tended to return to near baseline levels at periods of up to 1 year following medication withdrawal, although one third of the subjects continued to display atypical postural motion profiles at follow-up. Results provide within-subject evidence that tardive dyskinesia is associated with generalized changes in motor control and not simply peripheral disturbances of movement.

Full Text

Duke Authors

Cited Authors

  • Newell, KM; Ko, YG; Sprague, RL; Mahorney, SL; Bodfish, JW

Published Date

  • July 2002

Published In

Volume / Issue

  • 107 / 4

Start / End Page

  • 270 - 277

PubMed ID

  • 12069646

International Standard Serial Number (ISSN)

  • 0895-8017

Digital Object Identifier (DOI)

  • 10.1352/0895-8017(2002)107<0270:OODACI>2.0.CO;2


  • eng

Conference Location

  • United States