Agonist-antagonist combinations in opioid dependence: a translational approach.


Journal Article

The potential therapeutic benefits of co-administering opiate agonist and antagonist agents remain largely to be investigated. This paper focuses on the mechanisms of very low doses of naltrexone that help modulate the effects of methadone withdrawal and review pharmacological properties of the buprenorphine/naltrexone combination that support its clinical investigation. The bench-to-bedside development of the very low dose naltrexone treatment can serve as a translational paradigm to investigate and treat drug addiction. Further research on putative mechanisms elicited by the use of opioid agonist-antagonist combinations may lead to effective pharmacological alternatives to the gold standard methadone treatment, also useful for the management of the abuse of non opioid drugs and alcohol.

Full Text

Duke Authors

Cited Authors

  • Mannelli, P

Published Date

  • 2010

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 17 - 24

PubMed ID

  • 22448305

Pubmed Central ID

  • 22448305

International Standard Serial Number (ISSN)

  • 1970-1101


  • eng

Conference Location

  • Italy