Diagnostic value of indirect hemagglutination in the seroepidemiology of Shigella infections.
Published
Journal Article
To evaluate the usefulness of the indirect hemagglutination (IHA) test in the epidemiological investigation of shigellosis, single serum specimens were tested from 50 patients with Shigella dysenteriae 1 (Shiga bacillus) infections, 103 asymptomatic contacts of these cases, 267 adult and 100 student control, and serum specimens collected during two outbreaks caused by S. sonnei and one outbreak due to S. flexneri 6. In patients with S. dysenteriae 1, 74% demonstrated titers of greater than or equal to 1:40, with 50% showing titers of greater than or equal to 1:160, whereas in the controls 10.4% had titers of greater than or equal to 1:40 and only 0.3% had titers of greater than or equal to 1:160. IHA titers in serum specimens collected from patients with S. sonnei and S. flexneri 6 were too low to be considered diagnostic for individual patients, but were useful in analysis of group results. Groups of ill individuals yielded titers significantly higher than non-ill groups; however, titers from ill groups were usually less than 1:40. The IHA test for S. dysenteriae 1 antibodies serves as a valuable adjunct to the diagnosis of Shiga bacillus dysentery. In our laboratory, an IHA titer of 1:40 or 1:80 is a "borderline positive." Shiga bacillus dysentery is strongly indicated when IHA titers are greater than or equal to 1:60.
Full Text
Duke Authors
Cited Authors
- Patton, CM; Gangarosa, EJ; Weissman, JB; Merson, MH; Morris, GK
Published Date
- February 1, 1976
Published In
Volume / Issue
- 3 / 2
Start / End Page
- 143 - 148
PubMed ID
- 767361
Pubmed Central ID
- 767361
International Standard Serial Number (ISSN)
- 0095-1137
Language
- eng
Conference Location
- United States