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Diagnostic value of indirect hemagglutination in the seroepidemiology of Shigella infections.

Publication ,  Journal Article
Patton, CM; Gangarosa, EJ; Weissman, JB; Merson, MH; Morris, GK
Published in: J Clin Microbiol
February 1976

To evaluate the usefulness of the indirect hemagglutination (IHA) test in the epidemiological investigation of shigellosis, single serum specimens were tested from 50 patients with Shigella dysenteriae 1 (Shiga bacillus) infections, 103 asymptomatic contacts of these cases, 267 adult and 100 student control, and serum specimens collected during two outbreaks caused by S. sonnei and one outbreak due to S. flexneri 6. In patients with S. dysenteriae 1, 74% demonstrated titers of greater than or equal to 1:40, with 50% showing titers of greater than or equal to 1:160, whereas in the controls 10.4% had titers of greater than or equal to 1:40 and only 0.3% had titers of greater than or equal to 1:160. IHA titers in serum specimens collected from patients with S. sonnei and S. flexneri 6 were too low to be considered diagnostic for individual patients, but were useful in analysis of group results. Groups of ill individuals yielded titers significantly higher than non-ill groups; however, titers from ill groups were usually less than 1:40. The IHA test for S. dysenteriae 1 antibodies serves as a valuable adjunct to the diagnosis of Shiga bacillus dysentery. In our laboratory, an IHA titer of 1:40 or 1:80 is a "borderline positive." Shiga bacillus dysentery is strongly indicated when IHA titers are greater than or equal to 1:60.

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Published In

J Clin Microbiol

DOI

ISSN

0095-1137

Publication Date

February 1976

Volume

3

Issue

2

Start / End Page

143 / 148

Location

United States

Related Subject Headings

  • Shigella sonnei
  • Shigella flexneri
  • Shigella dysenteriae
  • Polysaccharides, Bacterial
  • Microbiology
  • Humans
  • Evaluation Studies as Topic
  • Dysentery, Bacillary
  • Disease Outbreaks
  • Diagnosis, Differential
 

Citation

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Patton, C. M., Gangarosa, E. J., Weissman, J. B., Merson, M. H., & Morris, G. K. (1976). Diagnostic value of indirect hemagglutination in the seroepidemiology of Shigella infections. J Clin Microbiol, 3(2), 143–148. https://doi.org/10.1128/jcm.3.2.143-148.1976
Patton, C. M., E. J. Gangarosa, J. B. Weissman, M. H. Merson, and G. K. Morris. “Diagnostic value of indirect hemagglutination in the seroepidemiology of Shigella infections.J Clin Microbiol 3, no. 2 (February 1976): 143–48. https://doi.org/10.1128/jcm.3.2.143-148.1976.
Patton CM, Gangarosa EJ, Weissman JB, Merson MH, Morris GK. Diagnostic value of indirect hemagglutination in the seroepidemiology of Shigella infections. J Clin Microbiol. 1976 Feb;3(2):143–8.
Patton, C. M., et al. “Diagnostic value of indirect hemagglutination in the seroepidemiology of Shigella infections.J Clin Microbiol, vol. 3, no. 2, Feb. 1976, pp. 143–48. Pubmed, doi:10.1128/jcm.3.2.143-148.1976.
Patton CM, Gangarosa EJ, Weissman JB, Merson MH, Morris GK. Diagnostic value of indirect hemagglutination in the seroepidemiology of Shigella infections. J Clin Microbiol. 1976 Feb;3(2):143–148.

Published In

J Clin Microbiol

DOI

ISSN

0095-1137

Publication Date

February 1976

Volume

3

Issue

2

Start / End Page

143 / 148

Location

United States

Related Subject Headings

  • Shigella sonnei
  • Shigella flexneri
  • Shigella dysenteriae
  • Polysaccharides, Bacterial
  • Microbiology
  • Humans
  • Evaluation Studies as Topic
  • Dysentery, Bacillary
  • Disease Outbreaks
  • Diagnosis, Differential