Biliary response to glucagon in humans.

Journal Article (Journal Article)

Glucagon has been demonstrated to have profound effect on biliary secretion in several species. Glucagon's biliary effects were studied in humans following biliary tract surgery. Nine patients underwent common bile duct exploration and insertion of a balloon-occludable t tube. An aliquot of the collected sample was kept and the enterohepatic circulation was maintained by reinfusion of the collected bile via the distal t-tube port. Glucagon increased bile flow and decreased cholesterol and phospholipid output during stable bile acid output. Furthermore high-performance liquid chromatographic analysis of bile acid profiles revealed no significant changes in bile salt species or conjugation after glucagon infusion. Glucagon is probably important in the physiologic regulation of biliary secretion in humans.

Full Text

Duke Authors

Cited Authors

  • Branum, GD; Bowers, BA; Watters, CR; Haebig, J; Cucchiaro, G; Farouk, M; Meyers, WC

Published Date

  • April 1991

Published In

Volume / Issue

  • 213 / 4

Start / End Page

  • 335 - 340

PubMed ID

  • 2009015

Pubmed Central ID

  • PMC1358352

International Standard Serial Number (ISSN)

  • 0003-4932

Digital Object Identifier (DOI)

  • 10.1097/00000658-199104000-00008


  • eng

Conference Location

  • United States