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Biliary response to glucagon and insulin following hepatic transplantation in humans.

Publication ,  Journal Article
Branum, GD; Bowers, BA; Watters, CR; Cucchiaro, G; Meyers, WC
Published in: J Surg Res
August 1990

Glucagon and insulin are postulated to be physiologic regulators of hepatic biliary secretion. Effects of these hormones were studied following orthotopic transplantation. Five adult hepatic graft recipients had triple lumen t-tubes placed at the time of surgery and were studied 3 months after surgery. Experiments were performed after cholangiographic confirmation of t-tube placement and function. After overnight fast, t-tubes were inflated and bile was collected. A small quantity was saved for analysis and the remainder was reinfused to maintain enterohepatic circulation. After 1 hr of observation, the patients received a 2-hr infusion of insulin (0.125 U kg-1 hr-1), glucagon (2 micrograms kg-1 hr-1), or 0.9% saline. During saline infusions, all parameters remained stable. As has been previously demonstrated in the canine model and intact patients, bile salt outputs were constant under all experimental conditions. Glucagon stimulated bile secretion by 30% (6.7 +/- 1.5 to 8.7 +/- 1.2 ml/15 min) and inhibited biliary cholesterol output by 47% (16.4 +/- 3.2 to 8.7 +/- 1.5 mg/15 min). Bile flow and lipid secretion were not affected by insulin. Glucagon had profound effects on bile flow and lipid secretion, suggesting effects independent of innervation, while insulin at this dose had no statistically significant effects.

Duke Scholars

Published In

J Surg Res

DOI

ISSN

0022-4804

Publication Date

August 1990

Volume

49

Issue

2

Start / End Page

121 / 125

Location

United States

Related Subject Headings

  • Surgery
  • Postoperative Period
  • Phospholipids
  • Liver Transplantation
  • Insulin
  • Humans
  • Glucagon
  • Cholesterol
  • Blood Glucose
  • Bile Acids and Salts
 

Citation

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Branum, G. D., Bowers, B. A., Watters, C. R., Cucchiaro, G., & Meyers, W. C. (1990). Biliary response to glucagon and insulin following hepatic transplantation in humans. J Surg Res, 49(2), 121–125. https://doi.org/10.1016/0022-4804(90)90249-2
Branum, G. D., B. A. Bowers, C. R. Watters, G. Cucchiaro, and W. C. Meyers. “Biliary response to glucagon and insulin following hepatic transplantation in humans.J Surg Res 49, no. 2 (August 1990): 121–25. https://doi.org/10.1016/0022-4804(90)90249-2.
Branum GD, Bowers BA, Watters CR, Cucchiaro G, Meyers WC. Biliary response to glucagon and insulin following hepatic transplantation in humans. J Surg Res. 1990 Aug;49(2):121–5.
Branum, G. D., et al. “Biliary response to glucagon and insulin following hepatic transplantation in humans.J Surg Res, vol. 49, no. 2, Aug. 1990, pp. 121–25. Pubmed, doi:10.1016/0022-4804(90)90249-2.
Branum GD, Bowers BA, Watters CR, Cucchiaro G, Meyers WC. Biliary response to glucagon and insulin following hepatic transplantation in humans. J Surg Res. 1990 Aug;49(2):121–125.
Journal cover image

Published In

J Surg Res

DOI

ISSN

0022-4804

Publication Date

August 1990

Volume

49

Issue

2

Start / End Page

121 / 125

Location

United States

Related Subject Headings

  • Surgery
  • Postoperative Period
  • Phospholipids
  • Liver Transplantation
  • Insulin
  • Humans
  • Glucagon
  • Cholesterol
  • Blood Glucose
  • Bile Acids and Salts