Skip to main content

Regulation of biliary protein secretion in dogs.

Publication ,  Journal Article
Rotolo, FS; Watters, CR; Xu, H; Quarfordt, SH; Meyers, WC
Published in: Proc Soc Exp Biol Med
February 1988

The biliary secretion of protein in response to bile acids and other agents known to increase bile flow was examined in a chronic bile fistula dog model. Infusion of 25, 50, or 75 mumole/kg/hr sodium taurocholate after 3 hr of bile fistulization increased biliary protein output significantly by 52, 86, and 108% respectively compared to preinfusion values. A proportionate increase in biliary albumin output during taurocholate choleresis was demonstrated. Protein outputs during bile fistulization without taurocholate replacement were unchanged. The non-micelle-forming bile acid dehydrocholate markedly increased bile flow but did not change protein output. Similarly, the hormonal choleretics glucagon and secretin caused significant decreases in biliary protein concentration but no change in protein output. These data indicate a correlation between biliary protein secretion and bile acid-dependent bile flow. It is likely that regulation of certain proteins is dependent on the micelle-forming properties of bile acids.

Duke Scholars

Published In

Proc Soc Exp Biol Med

DOI

ISSN

0037-9727

Publication Date

February 1988

Volume

187

Issue

2

Start / End Page

149 / 156

Location

United States

Related Subject Headings

  • Serum Albumin
  • Reference Values
  • Proteins
  • Phospholipids
  • Kinetics
  • Female
  • Dogs
  • Biochemistry & Molecular Biology
  • Bile Acids and Salts
  • Bile
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rotolo, F. S., Watters, C. R., Xu, H., Quarfordt, S. H., & Meyers, W. C. (1988). Regulation of biliary protein secretion in dogs. Proc Soc Exp Biol Med, 187(2), 149–156. https://doi.org/10.3181/00379727-187-42648
Rotolo, F. S., C. R. Watters, H. Xu, S. H. Quarfordt, and W. C. Meyers. “Regulation of biliary protein secretion in dogs.Proc Soc Exp Biol Med 187, no. 2 (February 1988): 149–56. https://doi.org/10.3181/00379727-187-42648.
Rotolo FS, Watters CR, Xu H, Quarfordt SH, Meyers WC. Regulation of biliary protein secretion in dogs. Proc Soc Exp Biol Med. 1988 Feb;187(2):149–56.
Rotolo, F. S., et al. “Regulation of biliary protein secretion in dogs.Proc Soc Exp Biol Med, vol. 187, no. 2, Feb. 1988, pp. 149–56. Pubmed, doi:10.3181/00379727-187-42648.
Rotolo FS, Watters CR, Xu H, Quarfordt SH, Meyers WC. Regulation of biliary protein secretion in dogs. Proc Soc Exp Biol Med. 1988 Feb;187(2):149–156.

Published In

Proc Soc Exp Biol Med

DOI

ISSN

0037-9727

Publication Date

February 1988

Volume

187

Issue

2

Start / End Page

149 / 156

Location

United States

Related Subject Headings

  • Serum Albumin
  • Reference Values
  • Proteins
  • Phospholipids
  • Kinetics
  • Female
  • Dogs
  • Biochemistry & Molecular Biology
  • Bile Acids and Salts
  • Bile