The in vitro photosensitivity of systemic lupus erythematosus skin fibroblasts.


Journal Article

To investigate the role of DNA damage in the pathogenesis of systemic lupus erythematosus (SLE), we studied the ability of skin fibroblasts derived from SLE patients to recover from ultraviolet (UV) light radiation of varying wavelengths. Four of five SLE cell strains were more sensitive to UV-C (254 nm), sun lamp, and UV-A (320 to 400 nm) light than were normal cells. SLE cellular recovery was most sensitive to broad spectrum, long wavelength light. This hypersensitivity did not appear to result from the UV light activation of a clastogenic factor. Experiments which examined the DNA repair capacity of irradiated cells indicated that SLE fibroblasts may be able to excise certain DNA lesions as well as normal cells. The mechanisms responsible for the hypersensitivity of SLE cells remain under investigation.

Full Text

Cited Authors

  • Zamansky, GB; Minka, DF; Deal, CL; Hendricks, K

Published Date

  • March 1, 1985

Published In

Volume / Issue

  • 134 / 3

Start / End Page

  • 1571 - 1576

PubMed ID

  • 3968426

Pubmed Central ID

  • 3968426

Electronic International Standard Serial Number (EISSN)

  • 1550-6606

International Standard Serial Number (ISSN)

  • 0022-1767


  • eng