Absence of a clinical correlation for complement-mediated, infection-enhancing antibodies in plasma or sera from HIV-1-infected individuals. Multicenter AIDS Cohort Study Group.


Journal Article

Neutralizing and complement-mediated infection-enhancing antibodies to HIV-1 were measured in sera or plasma from 54 HIV-1-positive individuals at various stages of disease, and from an additional 36 HIV-1-positive individuals for whom no clinical data were available. Antibodies were measured in microtiter infection assays utilizing MT-2 cells and the IIIB strain of HIV-1. The frequency of detection of both types of antibodies was identical, being 77 out of 90 cases (86%). Neutralizing and infection-enhancing antibodies were not always found together, and in four cases both were undetectable. No correlation was found between titers of either type of antibody and stage of disease. Furthermore, titers of infection-enhancing antibodies at early stages of disease did not predict rate of disease progression.

Full Text

Duke Authors

Cited Authors

  • Montefiori, DC; Lefkowitz, LB; Keller, RE; Holmberg, V; Sandstrom, E; Phair, JP

Published Date

  • May 1991

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 513 - 517

PubMed ID

  • 1863402

Pubmed Central ID

  • 1863402

International Standard Serial Number (ISSN)

  • 0269-9370

Digital Object Identifier (DOI)

  • 10.1097/00002030-199105000-00006


  • eng

Conference Location

  • England