Hypothalamic insufficiency: the cause of hypopituitarism in sarcoidosis.

Journal Article (Journal Article)

Ten patients with generalized sarcoidosis and hypopituitarism were studied. Six of these 10 patients presented with sarcoid involvement of the optic nerves resulting in asymmetric visual field defects. All patients had deficiencies of two or more anterior pituitary hormones and seven had abnormalities of water metabolism. Despite hypopituitarism, nine patients had a pituitary responsive to the synthetic hypothalamic releasing factors, thyrotropin releasing hormone and gonadotropin releasing hormone, and the tenth patient had a partially responsive pituitary. The demonstration of pituitary responsiveness allows us to infer hypothalamic insufficiency as the major cause for hypopituitarism in these patients. The combination of visual field defects and hypopituitarism in sarcoidosis is a medically treatable condition that simulates the clinical presentation of a pituitary tumor.

Full Text

Duke Authors

Cited Authors

  • Stuart, CA; Neelon, FA; Lebovitz, HE

Published Date

  • May 1, 1978

Published In

Volume / Issue

  • 88 / 5

Start / End Page

  • 589 - 594

PubMed ID

  • 646239

International Standard Serial Number (ISSN)

  • 0003-4819

Digital Object Identifier (DOI)

  • 10.7326/0003-4819-88-5-589


  • eng

Conference Location

  • United States