Oligoribonucleotides: improvement in chromatographic separation.


Journal Article

The separation of mixed oligoribonucleotides obtained from enzymatic digestion of soluble RNA into fractions containing mixed oligonucleotides of identical chain length is improved by absence of terminal phosphate. Each fraction may be separated into individual components by ionexchange (Dowex) chromatography. Combination of these two chromatographic procedures yields maximum information on primary structure of the oligonucleotides.

Full Text

Duke Authors

Cited Authors

  • Ishikura, H; Neelon, FA; Cantoni, GL

Published Date

  • July 15, 1966

Published In

Volume / Issue

  • 153 / 3733

Start / End Page

  • 300 - 301

PubMed ID

  • 17779999

Pubmed Central ID

  • 17779999

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.153.3733.300


  • eng

Conference Location

  • United States