Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma.
Publication
, Journal Article
Xu, X; Rock, JR; Lu, Y; Futtner, C; Schwab, B; Guinney, J; Hogan, BLM; Onaitis, MW
Published in: Proc Natl Acad Sci U S A
March 27, 2012
Identifying the cells of origin of lung cancer may lead to new therapeutic strategies. Previous work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct junction as a cancer cell of origin when a codon 12 K-Ras mutant is induced via adenoviral Cre inhalation. In the present study, we use two "knock-in" Cre-estrogen receptor alleles to inducibly express K-RasG12D in CC10(+) epithelial cells and Sftpc(+) type II alveolar cells of the adult mouse lung. Analysis of these mice identifies type II cells, Clara cells in the terminal bronchioles, and putative bronchoalveolar stem cells as cells of origin for K-Ras-induced lung hyperplasia. However, only type II cells appear to progress to adenocarcinoma.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Proc Natl Acad Sci U S A
DOI
EISSN
1091-6490
Publication Date
March 27, 2012
Volume
109
Issue
13
Start / End Page
4910 / 4915
Location
United States
Related Subject Headings
- Uteroglobin
- Transcriptome
- Time Factors
- SOXB1 Transcription Factors
- Pulmonary Surfactant-Associated Protein C
- Proto-Oncogene Proteins p21(ras)
- Peptides
- Oligonucleotide Array Sequence Analysis
- Mutant Proteins
- Models, Biological
Citation
APA
Chicago
ICMJE
MLA
NLM
Xu, X., Rock, J. R., Lu, Y., Futtner, C., Schwab, B., Guinney, J., … Onaitis, M. W. (2012). Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. Proc Natl Acad Sci U S A, 109(13), 4910–4915. https://doi.org/10.1073/pnas.1112499109
Xu, Xia, Jason R. Rock, Yun Lu, Christopher Futtner, Brian Schwab, Justin Guinney, Brigid L. M. Hogan, and Mark W. Onaitis. “Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma.” Proc Natl Acad Sci U S A 109, no. 13 (March 27, 2012): 4910–15. https://doi.org/10.1073/pnas.1112499109.
Xu X, Rock JR, Lu Y, Futtner C, Schwab B, Guinney J, et al. Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4910–5.
Xu, Xia, et al. “Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma.” Proc Natl Acad Sci U S A, vol. 109, no. 13, Mar. 2012, pp. 4910–15. Pubmed, doi:10.1073/pnas.1112499109.
Xu X, Rock JR, Lu Y, Futtner C, Schwab B, Guinney J, Hogan BLM, Onaitis MW. Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4910–4915.
Published In
Proc Natl Acad Sci U S A
DOI
EISSN
1091-6490
Publication Date
March 27, 2012
Volume
109
Issue
13
Start / End Page
4910 / 4915
Location
United States
Related Subject Headings
- Uteroglobin
- Transcriptome
- Time Factors
- SOXB1 Transcription Factors
- Pulmonary Surfactant-Associated Protein C
- Proto-Oncogene Proteins p21(ras)
- Peptides
- Oligonucleotide Array Sequence Analysis
- Mutant Proteins
- Models, Biological