B cell loss leading to remission in severe systemic lupus erythematosus.
Journal Article (Journal Article;Review)
Systemic lupus erythematosus (SLE) pathogenesis is mediated in part by autoantibodies. We describe a patient with central nervous system lupus who developed a loss of B cells with associated hypogammaglobulinemia and sinopulmonary infections requiring intravenous immunoglobulin. The SLE went into complete remission. Of 18 reported patients with SLE developing persistent hypogammaglobulinemia, only 5 patients including ours had a nearly complete loss of circulating B cells. Of those whose SLE and B cell status was reported, 5/5 with B cell loss and 1/10 without B cell loss experienced a durable response of SLE (p = 0.002). These cases illustrate that B cell ablative therapies may have efficacy for SLE.
Full Text
Duke Authors
Cited Authors
- Tarrant, TK; Frazer, DH; Aya-Ay, JP; Patel, DD
Published Date
- February 2003
Published In
Volume / Issue
- 30 / 2
Start / End Page
- 412 - 414
PubMed ID
- 12563705
International Standard Serial Number (ISSN)
- 0315-162X
Language
- eng
Conference Location
- Canada