B cell loss leading to remission in severe systemic lupus erythematosus.

Journal Article (Journal Article;Review)

Systemic lupus erythematosus (SLE) pathogenesis is mediated in part by autoantibodies. We describe a patient with central nervous system lupus who developed a loss of B cells with associated hypogammaglobulinemia and sinopulmonary infections requiring intravenous immunoglobulin. The SLE went into complete remission. Of 18 reported patients with SLE developing persistent hypogammaglobulinemia, only 5 patients including ours had a nearly complete loss of circulating B cells. Of those whose SLE and B cell status was reported, 5/5 with B cell loss and 1/10 without B cell loss experienced a durable response of SLE (p = 0.002). These cases illustrate that B cell ablative therapies may have efficacy for SLE.

Full Text

Duke Authors

Cited Authors

  • Tarrant, TK; Frazer, DH; Aya-Ay, JP; Patel, DD

Published Date

  • February 2003

Published In

Volume / Issue

  • 30 / 2

Start / End Page

  • 412 - 414

PubMed ID

  • 12563705

International Standard Serial Number (ISSN)

  • 0315-162X


  • eng

Conference Location

  • Canada