Metabolic reprogramming of the immune response in the tumor microenvironment.

Journal Article

A Division of Cancer Biology, NCI sponsored workshop, Metabolic Reprogramming of the Immune Response in the Tumor Microenvironment, was held October 2nd in Bethesda, MD. The purpose of the workshop was to bring together cancer cell biologists and immunologists to explore the mechanistic relationships between the metabolic pathways used by cancer cells and anti-tumor immune cells and how this information could be used to improve cancer immunotherapy. At the conclusion of the workshop a general discussion focused on defining the major challenges and opportunities concerning the impact of metabolism on anti-tumor immunity and cancer immunotherapy as well as what tools, technologies, resources or community efforts are required to accelerate research in this area. Overall, future studies need to consider how cancer cell metabolic pathways differ from activated lymphocytes in order to define a therapeutic window for cancer therapy. Further, studies aimed at reprogramming the metabolic qualities of T cells with the goal of improving immunotherapy were considered a promising avenue.

Full Text

Duke Authors

Cited Authors

  • McCarthy, SA; Mufson, RA; Pearce, EJ; Rathmell, JC; Howcroft, TK

Published Date

  • April 2013

Published In

Volume / Issue

  • 14 / 4

Start / End Page

  • 315 - 318

PubMed ID

  • 23358474

Pubmed Central ID

  • PMC3667870

Electronic International Standard Serial Number (EISSN)

  • 1555-8576

Digital Object Identifier (DOI)

  • 10.4161/cbt.23616


  • eng

Conference Location

  • United States