Matched and mismatched metabolic fuels in lymphocyte function.

Published

Journal Article (Review)

Immunological function requires metabolic support to suit the needs of lymphocytes at a variety of distinct differentiation and activation states. It is now evident that the signaling pathways that drive lymphocyte survival and activity can directly control cellular metabolism. This linkage provides a mechanism by which activation and specific signaling pathways provide a supply of appropriate and required nutrients to support cell functions in a pro-active supply rather than consumption-based metabolic model. In this way, the metabolism and fuel choices of lymphocytes are guided to specifically match the anticipated needs. If the fuel choice or metabolic pathways of lymphocytes are dysregulated, however, metabolic checkpoints can become activated to disrupt immunological function. These changes are now shown in several immunological diseases and may open new opportunities to selectively enhance or suppress specific immune functions through targeting of glucose, lipid, or amino acid metabolism.

Full Text

Duke Authors

Cited Authors

  • Caro-Maldonado, A; Gerriets, VA; Rathmell, JC

Published Date

  • December 2012

Published In

Volume / Issue

  • 24 / 6

Start / End Page

  • 405 - 413

PubMed ID

  • 23290889

Pubmed Central ID

  • 23290889

Electronic International Standard Serial Number (EISSN)

  • 1096-3618

International Standard Serial Number (ISSN)

  • 1044-5323

Digital Object Identifier (DOI)

  • 10.1016/j.smim.2012.12.002

Language

  • eng