Evidence-based clinical practice guidelines for managing depression in persons living with HIV.


Journal Article

Depressive symptoms and depression are prevalent among persons living with HIV (PLWH). Depression among PLWH is associated with a lower quality of life, reduced adherence to antiretroviral treatment, poorer self-care, worsened treatment outcomes, greater impairment in social and vocational functioning, and increased social isolation. Assessment of depression in PLWH is critical to facilitate referral and management. Fortunately, two simple screening questions can be used to assess for depression, and evidence supports the effective management of depression for PLWH. First-line treatment regimens for depression include selective serotonin reuptake inhibitors (SSRIs), cognitive behavioral therapy (CBT), or a combination of SSRI and CBT. This paper examines the contemporary evidence related to depression in the context of HIV infection. A case study has been included to illustrate an application of evidence-based treatment interventions recommended for clinical practice.

Full Text

Duke Authors

Cited Authors

  • Relf, MV; Eisbach, S; Okine, KN; Ward, T

Published Date

  • January 2013

Published In

Volume / Issue

  • 24 / 1 Suppl

Start / End Page

  • S15 - S28

PubMed ID

  • 23290374

Pubmed Central ID

  • 23290374

Electronic International Standard Serial Number (EISSN)

  • 1552-6917

International Standard Serial Number (ISSN)

  • 1055-3290

Digital Object Identifier (DOI)

  • 10.1016/j.jana.2012.05.007


  • eng