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Calcium channel inhibitors attenuate consumption of ethanol, sucrose and saccharin solutions in rats.

Publication ,  Journal Article
Pucilowski, O; Rezvani, AH; Overstreet, DH; Janowsky, DS
Published in: Behav Pharmacol
August 1994

Ca(2+) channel inhibitors suppress ethanol intake in various strains of alcohol-preferring rats. To test whether that inhibitory effect involves interference with the caloric consequences of preferred fluids, we compared the effects of two dihydropyridines, nicardipine and isradipine, and diltiazem, a benzothiazepine Ca(2+) channel inhibitor, on intake of and preference for 10% ethanol (v/v), 13.7% sucrose (w/v, isocaloric to 10% ethanol) and non-caloric 0.02% saccharin (w/v) solutions. All of these Ca(2+) channel inhibitors dose-dependently (1.25-5µmol/kg isradipine, 5-20µmol/kg nicardipine, 10-40µmol/kg diltiazem) inhibited ethanol intake in alcohol-preferring P rats. Nicardipine and isradipine, but not diltiazem, simultaneously increased water intake and attenuated preference for ethanol. No change in food pellet intake was found. Similar inhibition was observed with regard to sucrose and saccharin intake in Sprague-Dawley rats, although higher doses (> 10µmol/kg) were required to achieve that effect. No significant changes in sucrose preference, as opposed to consumption, were observed with any drug, and only nicardipine at its highest dose (20µmol/kg, b.i.d.) significantly (p < 0.05) decreased preference for saccharin. In conclusion, all three Ca(2+) channel inhibitors significantly suppress consumption of caloric solutions of ethanol and sucrose, as well as of non-caloric saccharin solution. Although an accompanying decrease, in preference is evident only for alcohol, it appears that these effects may be related to decreased palatability of flavored fluids. However, the contribution of changes in ethanol- and sucrose-induced caloric satiety cannot be ruled out.

Duke Scholars

Published In

Behav Pharmacol

DOI

EISSN

1473-5849

Publication Date

August 1994

Volume

5

Issue

4 And 5

Start / End Page

494 / 501

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • 5202 Biological psychology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
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ICMJE
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Pucilowski, O., Rezvani, A. H., Overstreet, D. H., & Janowsky, D. S. (1994). Calcium channel inhibitors attenuate consumption of ethanol, sucrose and saccharin solutions in rats. Behav Pharmacol, 5(4 And 5), 494–501. https://doi.org/10.1097/00008877-199408000-00010
Pucilowski, O., A. H. Rezvani, D. H. Overstreet, and D. S. Janowsky. “Calcium channel inhibitors attenuate consumption of ethanol, sucrose and saccharin solutions in rats.Behav Pharmacol 5, no. 4 And 5 (August 1994): 494–501. https://doi.org/10.1097/00008877-199408000-00010.
Pucilowski O, Rezvani AH, Overstreet DH, Janowsky DS. Calcium channel inhibitors attenuate consumption of ethanol, sucrose and saccharin solutions in rats. Behav Pharmacol. 1994 Aug;5(4 And 5):494–501.
Pucilowski, O., et al. “Calcium channel inhibitors attenuate consumption of ethanol, sucrose and saccharin solutions in rats.Behav Pharmacol, vol. 5, no. 4 And 5, Aug. 1994, pp. 494–501. Pubmed, doi:10.1097/00008877-199408000-00010.
Pucilowski O, Rezvani AH, Overstreet DH, Janowsky DS. Calcium channel inhibitors attenuate consumption of ethanol, sucrose and saccharin solutions in rats. Behav Pharmacol. 1994 Aug;5(4 And 5):494–501.

Published In

Behav Pharmacol

DOI

EISSN

1473-5849

Publication Date

August 1994

Volume

5

Issue

4 And 5

Start / End Page

494 / 501

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • 5202 Biological psychology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences
  • 1115 Pharmacology and Pharmaceutical Sciences