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Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium.

Publication ,  Journal Article
Kelemen, LE; Bandera, EV; Terry, KL; Rossing, MA; Brinton, LA; Doherty, JA; Ness, RB; Kjaer, SK; Chang-Claude, J; Köbel, M; Lurie, G; King, M ...
Published in: BMC Cancer
January 22, 2013

BACKGROUND: Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations. METHODS: We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol. RESULTS: Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations. CONCLUSIONS: We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.

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Published In

BMC Cancer

DOI

EISSN

1471-2407

Publication Date

January 22, 2013

Volume

13

Start / End Page

28

Location

England

Related Subject Headings

  • United States
  • Risk Factors
  • Risk Assessment
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Multivariate Analysis
  • Logistic Models
  • Incidence
  • Humans
 

Citation

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MLA
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Kelemen, L. E., Bandera, E. V., Terry, K. L., Rossing, M. A., Brinton, L. A., Doherty, J. A., … Ovarian Cancer Association Consortium, . (2013). Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium. BMC Cancer, 13, 28. https://doi.org/10.1186/1471-2407-13-28
Kelemen, Linda E., Elisa V. Bandera, Kathryn L. Terry, Mary Anne Rossing, Louise A. Brinton, Jennifer A. Doherty, Roberta B. Ness, et al. “Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium.BMC Cancer 13 (January 22, 2013): 28. https://doi.org/10.1186/1471-2407-13-28.
Kelemen LE, Bandera EV, Terry KL, Rossing MA, Brinton LA, Doherty JA, Ness RB, Kjaer SK, Chang-Claude J, Köbel M, Lurie G, Thompson PJ, Carney ME, Moysich K, Edwards R, Bunker C, Jensen A, Høgdall E, Cramer DW, Vitonis AF, Olson SH, King M, Chandran U, Lissowska J, Garcia-Closas M, Yang H, Webb PM, Schildkraut JM, Goodman MT, Risch HA, Australian Ovarian Cancer Study Group and Australian Cancer Study (Ovarian Cancer), Ovarian Cancer Association Consortium. Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium. BMC Cancer. 2013 Jan 22;13:28.
Journal cover image

Published In

BMC Cancer

DOI

EISSN

1471-2407

Publication Date

January 22, 2013

Volume

13

Start / End Page

28

Location

England

Related Subject Headings

  • United States
  • Risk Factors
  • Risk Assessment
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Multivariate Analysis
  • Logistic Models
  • Incidence
  • Humans