CASS in retrospect: lessons from the randomized cohort and registry. Coronary Artery Surgery Study.

Journal Article (Journal Article)

The Coronary Artery Surgery Study (CASS) was a prospective, randomized evaluation of the value of coronary artery bypass grafting compared with medical therapy for stable, mildly symptomatic coronary artery disease. Also, the CASS registry collected clinic information and follow-up data from 24,959 nonconsecutive patients undergoing cardiac catheterization from 1974 to 1979. CASS has had a major impact on current management of the coronary disease patient and represents an important contribution to the cardiovascular knowledge base. Despite the large size and valuable contributions of CASS, its findings have been widely misinterpreted, especially regarding indications for coronary artery bypass surgery. This review examines CASS from the viewpoint of its methodology and some of its many published reports. A full understanding of CASS is requisite to avoid clinical misapplication of the findings of this study.

Full Text

Duke Authors

Cited Authors

  • Holloway, JD; Schocken, DD

Published Date

  • May 1988

Published In

Volume / Issue

  • 295 / 5

Start / End Page

  • 424 - 432

PubMed ID

  • 3259835

International Standard Serial Number (ISSN)

  • 0002-9629

Digital Object Identifier (DOI)

  • 10.1097/00000441-198805000-00003


  • eng

Conference Location

  • United States