NLRP3 Inflammasome and MS/EAE.


Journal Article

Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules. Possible involvement of the NLRP3 inflammasome (or inflammasomes) in the development of multiple sclerosis (MS) was suggested in a number of studies. Recent studies showed that the NLRP3 inflammasome exacerbates experimental autoimmune encephalomyelitis (EAE), an animal model of MS, although EAE can also develop without the NLRP3 inflammasome. In this paper, we discuss the NLRP3 inflammasome in MS and EAE development.

Full Text

Duke Authors

Cited Authors

  • Inoue, M; Shinohara, ML

Published Date

  • 2013

Published In

Volume / Issue

  • 2013 /

Start / End Page

  • 859145 -

PubMed ID

  • 23365725

Pubmed Central ID

  • 23365725

International Standard Serial Number (ISSN)

  • 2090-0422

Digital Object Identifier (DOI)

  • 10.1155/2013/859145


  • eng

Conference Location

  • United States