Intracranial dual-mode IVUS and hyperthermia using circular arrays: preliminary experiments.

Journal Article

In this study, we investigated the feasibility of using 3.5-Fr (3 Fr = 1 mm) circular phased-array intravascular ultrasound (IVUS) catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: (1) by inserting a 3.5-Fr IVUS catheter through skull burr holes, for 20 MHz brain imaging in the pig model, and (2) by testing a modified circular array for therapy potential with 18.5-MHz and 9-MHz continuous wave (CW) excitation. The imaging transducer's performance was superior to our previous 9-MHz mechanical IVUS prototype. The therapy catheter transducer was driven by CW electrical power at 18.5 MHz, achieving temperature changes reaching +8°C at a depth of 2 mm in a human glioblastoma grown on the flank of a mouse with minimal transducer resistive heating of +2°C. Further hyperthermia trials showed that 9-MHz CW excitation produced temperature changes of +4.5°C at a depth of 12 mm-a sufficient temperature rise for our long-term goal of targeted, controlled drug release via thermosensitive liposomes for therapeutic treatment of 1-cm-diameter glioblastomas.

Full Text

Duke Authors

Cited Authors

  • Patel, V; Light, E; Herickhoff, C; Grant, G; Britz, G; Wilson, C; Palmeri, M; Smith, S

Published Date

  • January 2013

Published In

Volume / Issue

  • 35 / 1

Start / End Page

  • 17 - 29

PubMed ID

  • 23287504

International Standard Serial Number (ISSN)

  • 0161-7346

Digital Object Identifier (DOI)

  • 10.1177/0161734612469372

Language

  • eng

Conference Location

  • England