Intracranial dual-mode IVUS and hyperthermia using circular arrays: preliminary experiments.
Journal Article (Journal Article)
In this study, we investigated the feasibility of using 3.5-Fr (3 Fr = 1 mm) circular phased-array intravascular ultrasound (IVUS) catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: (1) by inserting a 3.5-Fr IVUS catheter through skull burr holes, for 20 MHz brain imaging in the pig model, and (2) by testing a modified circular array for therapy potential with 18.5-MHz and 9-MHz continuous wave (CW) excitation. The imaging transducer's performance was superior to our previous 9-MHz mechanical IVUS prototype. The therapy catheter transducer was driven by CW electrical power at 18.5 MHz, achieving temperature changes reaching +8°C at a depth of 2 mm in a human glioblastoma grown on the flank of a mouse with minimal transducer resistive heating of +2°C. Further hyperthermia trials showed that 9-MHz CW excitation produced temperature changes of +4.5°C at a depth of 12 mm-a sufficient temperature rise for our long-term goal of targeted, controlled drug release via thermosensitive liposomes for therapeutic treatment of 1-cm-diameter glioblastomas.
Full Text
Duke Authors
Cited Authors
- Patel, V; Light, E; Herickhoff, C; Grant, G; Britz, G; Wilson, C; Palmeri, M; Smith, S
Published Date
- January 2013
Published In
Volume / Issue
- 35 / 1
Start / End Page
- 17 - 29
PubMed ID
- 23287504
Pubmed Central ID
- PMC3823244
International Standard Serial Number (ISSN)
- 0161-7346
Digital Object Identifier (DOI)
- 10.1177/0161734612469372
Language
- eng
Conference Location
- England