Skip to main content
Journal cover image

Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients.

Publication ,  Journal Article
Fräki, JE; Jakoi, L; Davies, AO; Lefkowitz, RJ; Snyderman, R; Lazarus, GS
Published in: J Invest Dermatol
September 1983

Psoriatic patients, particularly those with psoriatic arthritis, have neutrophilic and eosinophilic leukocytosis. Isolated polymorphonuclear leukocytes (PMNLs) from psoriatic patients have normal concentrations of proteolytic enzymes and they have beta-adrenergic receptors of normal density and affinity. PMNLs from psoriatic patients responded normally to the synthetic chemotactic peptide, f-Met-Leu-Phe (formyl-methionine-leucine-phenylalanine). The chemotactic activities of sera from psoriatic patients were similar to those of normal sera. Sera from psoriatic patients enhanced chemokinesis of PMNLs more than normal control sera at a final concentration of 1%; no difference in chemokinetic response between psoriatic and normal sera was found at serum concentrations greater than 2.5%. This study suggests that the peripheral PMNLs from psoriatic patients are normal, but the sera of psoriatic patients has more chemokinetic activity for PMNLs than does normal serum.

Duke Scholars

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

September 1983

Volume

81

Issue

3

Start / End Page

254 / 257

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Psoriasis
  • Peptide Hydrolases
  • Oligopeptides
  • Neutrophils
  • N-Formylmethionine Leucyl-Phenylalanine
  • N-Formylmethionine
  • Humans
  • Dermatology & Venereal Diseases
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fräki, J. E., Jakoi, L., Davies, A. O., Lefkowitz, R. J., Snyderman, R., & Lazarus, G. S. (1983). Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients. J Invest Dermatol, 81(3), 254–257. https://doi.org/10.1111/1523-1747.ep12518273
Fräki, J. E., L. Jakoi, A. O. Davies, R. J. Lefkowitz, R. Snyderman, and G. S. Lazarus. “Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients.J Invest Dermatol 81, no. 3 (September 1983): 254–57. https://doi.org/10.1111/1523-1747.ep12518273.
Journal cover image

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

September 1983

Volume

81

Issue

3

Start / End Page

254 / 257

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Psoriasis
  • Peptide Hydrolases
  • Oligopeptides
  • Neutrophils
  • N-Formylmethionine Leucyl-Phenylalanine
  • N-Formylmethionine
  • Humans
  • Dermatology & Venereal Diseases