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Histamine-releasing factor generated by the interaction of endotoxin with hamster serum.

Publication ,  Journal Article
Hook, WA; Snyderman, R; Mergenhagen, SE
Published in: Infect Immun
October 1970

Injection of hamsters with endotoxin (LPS) resulted, 4 to 14 days later, in a marked decline in the mast cell count and in a reduction of the available histamine content of cells obtained by peritoneal lavage. The release of histamine from isolated peritoneal hamster mast cells in vitro could be achieved by incubating LPS with fresh hamster serum followed by addition of mast cells and a second incubation. The generation of a histamine-releasing factor from serum could be inhibited by conditions which inhibit the consumption of complement by LPS. Several substances could be substituted for LPS in the generation of histamine-releasing activity including heat-aggregated human gamma globulin, zymosan, purified cobra venom factor, and washed antigen-antibody precipitates. With all of these agents, the generation of a histamine-releasing substance from hamster serum was accompanied by consumption of hemolytic complement. The results suggest that LPS indirectly leads to the release of histamine from mast cells as a result of interactions with the complement system.

Duke Scholars

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

October 1970

Volume

2

Issue

4

Start / End Page

462 / 467

Location

United States

Related Subject Headings

  • Microbiology
  • 3207 Medical microbiology
  • 3204 Immunology
  • 3107 Microbiology
  • 11 Medical and Health Sciences
  • 07 Agricultural and Veterinary Sciences
  • 06 Biological Sciences
 

Citation

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MLA
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Hook, W. A., Snyderman, R., & Mergenhagen, S. E. (1970). Histamine-releasing factor generated by the interaction of endotoxin with hamster serum. Infect Immun, 2(4), 462–467. https://doi.org/10.1128/iai.2.4.462-467.1970
Hook, W. A., R. Snyderman, and S. E. Mergenhagen. “Histamine-releasing factor generated by the interaction of endotoxin with hamster serum.Infect Immun 2, no. 4 (October 1970): 462–67. https://doi.org/10.1128/iai.2.4.462-467.1970.
Hook WA, Snyderman R, Mergenhagen SE. Histamine-releasing factor generated by the interaction of endotoxin with hamster serum. Infect Immun. 1970 Oct;2(4):462–7.
Hook, W. A., et al. “Histamine-releasing factor generated by the interaction of endotoxin with hamster serum.Infect Immun, vol. 2, no. 4, Oct. 1970, pp. 462–67. Pubmed, doi:10.1128/iai.2.4.462-467.1970.
Hook WA, Snyderman R, Mergenhagen SE. Histamine-releasing factor generated by the interaction of endotoxin with hamster serum. Infect Immun. 1970 Oct;2(4):462–467.

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

October 1970

Volume

2

Issue

4

Start / End Page

462 / 467

Location

United States

Related Subject Headings

  • Microbiology
  • 3207 Medical microbiology
  • 3204 Immunology
  • 3107 Microbiology
  • 11 Medical and Health Sciences
  • 07 Agricultural and Veterinary Sciences
  • 06 Biological Sciences