The SNO-proteome: causation and classifications.


Journal Article (Review)

Cell signaling is a complex and highly regulated process. Post-translational modifications of proteins serve to sense and transduce cellular signals in a precisely coordinated manner. It is increasingly recognized that protein S-nitrosylation, the addition of a nitric oxide group to cysteine thiols, serves an important role in a wide range of signaling pathways. In spite of the large number of SNO-proteins now identified (∼1000), the observed specificity of S-nitrosylation in terms of target proteins and specific cysteines within modified proteins is incompletely understood. Here we review the progress made in S-nitrosylation detection methods that have facilitated the study of the SNO-proteome under physiological and pathophysiological conditions, and some factors important in determining the SNO-proteome. Classification schemes for emergent denitrosylases and prospective 'protein S-nitrosylases' are provided.

Full Text

Duke Authors

Cited Authors

  • Seth, D; Stamler, JS

Published Date

  • February 2011

Published In

Volume / Issue

  • 15 / 1

Start / End Page

  • 129 - 136

PubMed ID

  • 21087893

Pubmed Central ID

  • 21087893

Electronic International Standard Serial Number (EISSN)

  • 1879-0402

Digital Object Identifier (DOI)

  • 10.1016/j.cbpa.2010.10.012


  • eng

Conference Location

  • England