Protein denitrosylation: enzymatic mechanisms and cellular functions.


Journal Article (Review)

S-Nitrosylation, the redox-based modification of Cys thiol side chains by nitric oxide, is a common mechanism in signal transduction. Dysregulated S-nitrosylation contributes to a range of human pathologies. New roles for protein denitrosylation in regulating S-nitrosylation are being revealed. Recently, several denitrosylases - the enzymes that mediate Cys denitrosylation - have been discovered, of which two enzyme systems in particular, the S-nitrosoglutathione reductase and thioredoxin systems, have been shown to be physiologically relevant. These highly conserved enzymes regulate signalling through multiple classes of receptors and influence diverse cellular responses. In addition, they protect from nitrosative stress in microorganisms, mammals and plants, thereby exerting profound effects on host-microbe interactions and innate immunity.

Full Text

Duke Authors

Cited Authors

  • Benhar, M; Forrester, MT; Stamler, JS

Published Date

  • October 2009

Published In

Volume / Issue

  • 10 / 10

Start / End Page

  • 721 - 732

PubMed ID

  • 19738628

Pubmed Central ID

  • 19738628

Electronic International Standard Serial Number (EISSN)

  • 1471-0080

Digital Object Identifier (DOI)

  • 10.1038/nrm2764


  • eng

Conference Location

  • England