Protein denitrosylation: enzymatic mechanisms and cellular functions.
Published
Journal Article (Review)
S-Nitrosylation, the redox-based modification of Cys thiol side chains by nitric oxide, is a common mechanism in signal transduction. Dysregulated S-nitrosylation contributes to a range of human pathologies. New roles for protein denitrosylation in regulating S-nitrosylation are being revealed. Recently, several denitrosylases - the enzymes that mediate Cys denitrosylation - have been discovered, of which two enzyme systems in particular, the S-nitrosoglutathione reductase and thioredoxin systems, have been shown to be physiologically relevant. These highly conserved enzymes regulate signalling through multiple classes of receptors and influence diverse cellular responses. In addition, they protect from nitrosative stress in microorganisms, mammals and plants, thereby exerting profound effects on host-microbe interactions and innate immunity.
Full Text
Duke Authors
Cited Authors
- Benhar, M; Forrester, MT; Stamler, JS
Published Date
- October 2009
Published In
Volume / Issue
- 10 / 10
Start / End Page
- 721 - 732
PubMed ID
- 19738628
Pubmed Central ID
- 19738628
Electronic International Standard Serial Number (EISSN)
- 1471-0080
Digital Object Identifier (DOI)
- 10.1038/nrm2764
Language
- eng
Conference Location
- England