A SNO storm in skeletal muscle.

Journal Article

Dysregulated S-nitrosylation of proteins characterizes a broad array of human disorders, but its role in disease etiology is not well understood. Two new studies (Durham et al., 2008; Bellinger et al., 2008) now show that hyper-S-nitrosylation of the ryanodine receptor calcium release channel (RyR1) in skeletal muscle disrupts calcium ion flux. This disruption underlies the impaired contractility and cellular damage of skeletal muscle during strenuous exercise and in a spectrum of congenital muscle disorders including malignant hyperthermia.

Full Text

Duke Authors

Cited Authors

  • Stamler, JS; Sun, Q-A; Hess, DT

Published Date

  • April 4, 2008

Published In

Volume / Issue

  • 133 / 1

Start / End Page

  • 33 - 35

PubMed ID

  • 18394987

Pubmed Central ID

  • 18394987

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2008.03.013


  • eng

Conference Location

  • United States