NO/redox disequilibrium in the failing heart and cardiovascular system.

Journal Article (Journal Article;Review)

There is growing evidence that the altered production and/or spatiotemporal distribution of reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the failing heart and vascular tree, which contribute to the abnormal cardiac and vascular phenotypes that characterize the failing cardiovascular system. These derangements at the integrated system level can be interpreted at the cellular and molecular levels in terms of adverse effects on signaling elements in the heart, vasculature, and blood that subserve cardiac and vascular homeostasis.

Full Text

Duke Authors

Cited Authors

  • Hare, JM; Stamler, JS

Published Date

  • March 2005

Published In

Volume / Issue

  • 115 / 3

Start / End Page

  • 509 - 517

PubMed ID

  • 15765132

Pubmed Central ID

  • 15765132

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI24459


  • eng

Conference Location

  • United States