Physiology of nitric oxide in skeletal muscle.


Journal Article (Review)

In the past five years, skeletal muscle has emerged as a paradigm of "nitric oxide" (NO) function and redox-related signaling in biology. All major nitric oxide synthase (NOS) isoforms, including a muscle-specific splice variant of neuronal-type (n) NOS, are expressed in skeletal muscles of all mammals. Expression and localization of NOS isoforms are dependent on age and developmental stage, innervation and activity, history of exposure to cytokines and growth factors, and muscle fiber type and species. nNOS in particular may show a fast-twitch muscle predominance. Muscle NOS localization and activity are regulated by a number of protein-protein interactions and co- and/or posttranslational modifications. Subcellular compartmentalization of the NOSs enables distinct functions that are mediated by increases in cGMP and by S-nitrosylation of proteins such as the ryanodine receptor-calcium release channel. Skeletal muscle functions regulated by NO or related molecules include force production (excitation-contraction coupling), autoregulation of blood flow, myocyte differentiation, respiration, and glucose homeostasis. These studies provide new insights into fundamental aspects of muscle physiology, cell biology, ion channel physiology, calcium homeostasis, signal transduction, and the biochemistry of redox-related systems.

Full Text

Duke Authors

Cited Authors

  • Stamler, JS; Meissner, G

Published Date

  • January 2001

Published In

Volume / Issue

  • 81 / 1

Start / End Page

  • 209 - 237

PubMed ID

  • 11152758

Pubmed Central ID

  • 11152758

International Standard Serial Number (ISSN)

  • 0031-9333

Digital Object Identifier (DOI)

  • 10.1152/physrev.2001.81.1.209


  • eng

Conference Location

  • United States