NO: an inhibitor of cell death.
Published
Journal Article (Review)
Nitric oxide (NO) or related molecules of both endogenous and exogenous origin inhibit programmed cell death in a variety of cells and tissues. This general protective function is largely independent of the apoptotic stimulus. S-nitrosylation of the catalytic-site cysteine of caspases is a well-established and possibly widespread mechanism of enzyme inhibition that protects from cell death. However, NO may inhibit apoptosis by additional mechanisms. The physiological and pathological significance of NO's anti-apoptotic activity remains to be determined in most cases.
Full Text
Duke Authors
Cited Authors
- Liu, L; Stamler, JS
Published Date
- October 1999
Published In
Volume / Issue
- 6 / 10
Start / End Page
- 937 - 942
PubMed ID
- 10556969
Pubmed Central ID
- 10556969
International Standard Serial Number (ISSN)
- 1350-9047
Digital Object Identifier (DOI)
- 10.1038/sj.cdd.4400578
Language
- eng
Conference Location
- England