NO: an inhibitor of cell death.

Published

Journal Article (Review)

Nitric oxide (NO) or related molecules of both endogenous and exogenous origin inhibit programmed cell death in a variety of cells and tissues. This general protective function is largely independent of the apoptotic stimulus. S-nitrosylation of the catalytic-site cysteine of caspases is a well-established and possibly widespread mechanism of enzyme inhibition that protects from cell death. However, NO may inhibit apoptosis by additional mechanisms. The physiological and pathological significance of NO's anti-apoptotic activity remains to be determined in most cases.

Full Text

Duke Authors

Cited Authors

  • Liu, L; Stamler, JS

Published Date

  • October 1999

Published In

Volume / Issue

  • 6 / 10

Start / End Page

  • 937 - 942

PubMed ID

  • 10556969

Pubmed Central ID

  • 10556969

International Standard Serial Number (ISSN)

  • 1350-9047

Digital Object Identifier (DOI)

  • 10.1038/sj.cdd.4400578

Language

  • eng

Conference Location

  • England