Biochemistry of nitric oxide and its redox-activated forms.
Published
Journal Article (Review)
Nitric oxide (NO.), a potentially toxic molecule, has been implicated in a wide range of biological functions. Details of its biochemistry, however, remain poorly understood. The broader chemistry of nitrogen monoxide (NO) involves a redox array of species with distinctive properties and reactivities: NO+ (nitrosonium), NO., and NO- (nitroxyl anion). The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.
Full Text
Duke Authors
Cited Authors
- Stamler, JS; Singel, DJ; Loscalzo, J
Published Date
- December 18, 1992
Published In
Volume / Issue
- 258 / 5090
Start / End Page
- 1898 - 1902
PubMed ID
- 1281928
Pubmed Central ID
- 1281928
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.1281928
Language
- eng
Conference Location
- United States