Biochemistry of nitric oxide and its redox-activated forms.

Published

Journal Article (Review)

Nitric oxide (NO.), a potentially toxic molecule, has been implicated in a wide range of biological functions. Details of its biochemistry, however, remain poorly understood. The broader chemistry of nitrogen monoxide (NO) involves a redox array of species with distinctive properties and reactivities: NO+ (nitrosonium), NO., and NO- (nitroxyl anion). The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.

Full Text

Duke Authors

Cited Authors

  • Stamler, JS; Singel, DJ; Loscalzo, J

Published Date

  • December 18, 1992

Published In

Volume / Issue

  • 258 / 5090

Start / End Page

  • 1898 - 1902

PubMed ID

  • 1281928

Pubmed Central ID

  • 1281928

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1281928

Language

  • eng

Conference Location

  • United States