The antiplatelet effects of organic nitrates and related nitroso compounds in vitro and in vivo and their relevance to cardiovascular disorders.

Journal Article (Review)

Organic nitrates, cornerstones of antianginal therapy, are believed to exert their principal anti-ischemic benefit by relaxing vascular smooth muscle. Recent evidence suggests that these compounds and related nitro(so) vasodilators are also potent platelet inhibitors. In view of the well recognized role of thrombotic events mediated by platelets in acute coronary syndromes, the antiplatelet effect of nitrates may also be of mechanistic importance in the treatment of these disorders. This review details the biochemical mechanism by which nitro(so) compounds inhibit platelet function and summarizes the in vitro and in vivo evidence that supports their antithrombotic effects.

Full Text

Duke Authors

Cited Authors

  • Stamler, JS; Loscalzo, J

Published Date

  • November 15, 1991

Published In

Volume / Issue

  • 18 / 6

Start / End Page

  • 1529 - 1536

PubMed ID

  • 1939957

Pubmed Central ID

  • 1939957

International Standard Serial Number (ISSN)

  • 0735-1097

Digital Object Identifier (DOI)

  • 10.1016/0735-1097(91)90686-4


  • eng

Conference Location

  • United States