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Thrombotic microangiopathy in anti-glomerular basement membrane glomerulonephritis.

Publication ,  Journal Article
Stave, GM; Croker, BP
Published in: Arch Pathol Lab Med
September 1984

A review was made of the clinical histories, treatment, and renal histologic features of 12 patients with anti-glomerular basement membrane antibody-induced glomerulonephritis (anti-GBM disease). Two patients had milder histopathologic changes in their kidney biopsy specimens and achieved clinical remission. The other ten patients with severe lesions in their biopsy specimens progressed to renal failure. In addition, vascular lesions of thrombotic microangiopathy were present in six of 12 patients. Six patients had clinical laboratory evidence of microangiopathic hemolytic anemia. There are two important points to be noted from this study. First, the kidney biopsy specimen may be a useful indicator of disease severity and prognosis. Second, clinical laboratory or histologic evidence of thrombotic microangiopathy may occur in 75% of patients with anti-GBM disease.

Duke Scholars

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

September 1984

Volume

108

Issue

9

Start / End Page

747 / 751

Location

United States

Related Subject Headings

  • Thrombosis
  • Retrospective Studies
  • Prognosis
  • Pathology
  • Middle Aged
  • Microscopy, Fluorescence
  • Microscopy, Electron
  • Microcirculation
  • Male
  • Kidney Glomerulus
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Stave, G. M., & Croker, B. P. (1984). Thrombotic microangiopathy in anti-glomerular basement membrane glomerulonephritis. Arch Pathol Lab Med, 108(9), 747–751.
Stave, G. M., and B. P. Croker. “Thrombotic microangiopathy in anti-glomerular basement membrane glomerulonephritis.Arch Pathol Lab Med 108, no. 9 (September 1984): 747–51.
Stave GM, Croker BP. Thrombotic microangiopathy in anti-glomerular basement membrane glomerulonephritis. Arch Pathol Lab Med. 1984 Sep;108(9):747–51.
Stave, G. M., and B. P. Croker. “Thrombotic microangiopathy in anti-glomerular basement membrane glomerulonephritis.Arch Pathol Lab Med, vol. 108, no. 9, Sept. 1984, pp. 747–51.
Stave GM, Croker BP. Thrombotic microangiopathy in anti-glomerular basement membrane glomerulonephritis. Arch Pathol Lab Med. 1984 Sep;108(9):747–751.

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

September 1984

Volume

108

Issue

9

Start / End Page

747 / 751

Location

United States

Related Subject Headings

  • Thrombosis
  • Retrospective Studies
  • Prognosis
  • Pathology
  • Middle Aged
  • Microscopy, Fluorescence
  • Microscopy, Electron
  • Microcirculation
  • Male
  • Kidney Glomerulus