In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains.

Journal Article (Journal Article)

Due to the limited number of antifungals and the emergence of resistance, new therapies against invasive aspergillosis are needed. We show that calcineurin inhibitors are active in vitro against both azole- and echinocandin-resistant Aspergillus fumigatus strains. The heat shock protein 90 (Hsp90) inhibitor geldanamycin had modest activity when used alone, but its combination with caspofungin or tacrolimus (FK506) resulted in fungicidal activity against azole-resistant strains. Targeting the Hsp90-calcineurin axis is a promising alternative strategy against azole-resistant A. fumigatus strains.

Full Text

Duke Authors

Cited Authors

  • Lamoth, F; Juvvadi, PR; Gehrke, C; Steinbach, WJ

Published Date

  • February 2013

Published In

Volume / Issue

  • 57 / 2

Start / End Page

  • 1035 - 1039

PubMed ID

  • 23165466

Pubmed Central ID

  • PMC3553695

Electronic International Standard Serial Number (EISSN)

  • 1098-6596

Digital Object Identifier (DOI)

  • 10.1128/AAC.01857-12


  • eng

Conference Location

  • United States